Quantum Biosensors on Chip: A Review from Electronic and Photonic Integrated Circuits to Future Integrated Quantum Photonic Circuits

Quantum biosensors offer a promising route to overcome the sensitivity and specificity limitations of conventional biosensing technologies. Their ability to detect biochemical signals at extremely low concentrations makes them strong candidates for next-generation sensing systems. This paper reviews the current state of quantum biosensors and discusses their future implementation in chip-scale platforms that combine microelectronic and photonic technologies. It covers key quantum biosensing approaches including quantum dots (QDs), and nitrogen-vacancy (NV) centers. This paper also considers their potential compatibility with electronic integrated circuits (EICs), photonic integrated circuits (PICs) and integrated quantum photonic (IQP) systems for future biosensing applications. To our knowledge, this is the first review to systematically connect quantum biosensing technologies with the development of microelectronic and photonic chip-based devices. The goal is to clarify the technological trajectory toward compact, scalable, and high-performance quantum biosensing systems.