Journal article
How Sodium and Calcium Ions Pass Through Batrachotoxin-Bound Sodium Channel
Abstract
Steroidal sodium channel agonist batrachotoxin (BTX), one of the most potent animal toxins, dramatically increases calcium permeation and alters other channel characteristics. In a cryoEM structure of rat sodium channel Nav1.5 with two BTX-B molecules, one toxin binds between repeats III and IV and exposes to the pore lumen two oxygen atoms and protonatable nitrogen. The mechanism of ion permeation and selectivity in BTX-bound channel is …
Authors
Zhorov BS
Journal
Toxins, Vol. 17, No. 10,
Publisher
MDPI
DOI
10.3390/toxins17100520
ISSN
2072-6651