Journal article
Exploring radiomic and topological features to evaluate treatment response in rectal cancer
Abstract
Objective.This study investigates the potential of topological data analysis (TDA) in conjunction with conventional radiomics applied to longitudinal T2-weighted magnetic resonance imaging (MRI) to evaluate treatment response following neoadjuvant therapy, with or without anti-CD40 immunotherapy, in patients with locally advanced rectal cancer.Approach.Paired pre- and post-treatment MRIs from 21 patients enrolled in the INNATE trial …
Authors
Zhang H; Liu J; Rajamohan N; Sanford NN; Khatri G; Rodriguez AP; Rajaram S; Jiang S; Timmerman R; Aguilera T
Journal
Physics in Medicine and Biology, Vol. 70, No. 21,
Publisher
IOP Publishing
Publication Date
November 2, 2025
DOI
10.1088/1361-6560/ae117f
ISSN
0031-9155