Journal article
Protective Role for Itaconate During Inhaled Allergen Challenge
Abstract
BACKGROUND: Asthma is a chronic, heterogeneous disease characterised by airway remodelling, inflammation, and mucus production. Airway macrophages' functions are underpinned by changes in cellular metabolism. The TCA cycle-derived metabolite itaconic acid (whose synthesis is mediated by aconitate decarboxylase) is a master regulator of macrophage function; however, its role during inhaled allergen challenge is not clear. The objective of this …
Authors
Albers GJ; Ogger PP; Michalaki C; Stölting H; Walker SA; Caldwell A; Halket JM; Duvall K; Batool A; Joshi L
Journal
Allergy, , ,
Publisher
Wiley
Publication Date
October 24, 2025
DOI
10.1111/all.70107
ISSN
0001-5148