Journal article
Progress of Zelen’s design and its application value in clinical research
Abstract
Objective To systematically reviewed the progress of Zelen’s design and its modifications in clinical research and clarified its methodological elements, advantages, and limitations. Methods A systematic literature search was conducted for Zelen’s design from databases. The data were extracted. Results One hundred and twenty-four trials were included. The dominant disease in this design was mental disorders, followed by osteoarthrosis diseases, …
Authors
Lin R; Lin T; Lu X; Chen Y; Zhou Q; Liu J; Zhang Y
Journal
Chinese Journal of Evidence Based Medicine, Vol. 25, No. 9, pp. 1071–1077
Publication Date
January 1, 2025
DOI
10.7507/1672-2531.202502116
ISSN
1672-2531