Mucoadhesive micelles for ophthalmic drug delivery.

The most common formulation for treating ocular conditions is topical eyedrops, despite their well-documented inefficiency. In this study, mucoadhesive nano-micelles were developed to overcome the poor efficacy of topical eyedrops in the treatment of dry eye disease. The micelles contained a pre-activated thiomer capable of releasing mucolytic N-acetylcysteine upon covalent disulfide exchange with the natural mucus layer which covers the …