Sensing of Long-Chain Fatty Acyl-CoA Esters by AMPK

Fatty acids are utilized to maintain cellular energy/adenine nucleotide balance under times of energetic stress such as during endurance exercise or fasting. It has long been recognized that fatty acids stimulate their own oxidation through a mechanism involving allosteric inhibition of acetyl-CoA carboxylase (ACC) and reductions in malonyl-CoA. We have recently described a parallel pathway by which long-chain fatty acid-CoAs bind to and …