Journal article
A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types
Abstract
Identifying tumor-specific T cell clones that mediate immunotherapy responses remains challenging. Mutation-associated neoantigen (MANA) -specific CD8+ tumor-infiltrating lymphocytes (TIL) have been shown to express high levels of CXCL13 and CD39 (ENTPD1), and low IL-7 receptor (IL7R) levels in many cancer types, but their collective relevance to T cell functionality has not been established. Here we present an integrative tool to identify …
Authors
Zeng Z; Zhang T; Zhang J; Li S; Connor S; Zhang B; Zhao Y; Wilson J; Singh D; Kulikauskas R
Journal
Nature Communications, Vol. 16, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-024-55059-3
ISSN
2041-1723