Journal article
Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation
Abstract
During gastrulation, Wnt-β-catenin signaling dictates lineage bifurcation generating different mesoderm cell types. However, the specific role of Wnt receptors in mesoderm specification remains elusive. Using selective Frizzled (FZD) and LRP5/6 antibody-based agonists, we examined FZD receptors' function during directed mesoderm differentiation of human pluripotent stem cells (hPSCs). We found that FZD2 and FZD7 receptors are expressed at the …
Authors
Chidiac R; Yang A; Kubarakos E; Mikolajewicz N; Han H; Almeida MP; Thibeault PE; Lin S; MacLeod G; Gratton J-P
Journal
Stem Cell Reports, Vol. 20, No. 2,
Publisher
Elsevier
Publication Date
February 2025
DOI
10.1016/j.stemcr.2024.102391
ISSN
2213-6711