Journal article
Delivery of Salbutamol Pressurized Metered-Dose Inhaler Administered Via Small-Volume Spacer Devices in Intubated, Spontaneously Breathing Rabbits
Abstract
Little is known about the ability of small-volume valved spacer devices to deliver a significant amount of an aerosolized drug to the lungs of babies. This study compared the in vitro delivery of salbutamol administered via Aerochamber-Infant (145 mL), Babyhaler (350 mL), and metallic NES-spacer (250 mL), as well as the in vivo delivery using an animal model. The lung deposition study of technetium-99m–labeled salbutamol was conducted in six …
Authors
Dubus J-C; Rhem R; Monkman S; Dolovich M
Journal
Pediatric Research, Vol. 50, No. 3, pp. 384–389
Publisher
Springer Nature
Publication Date
September 2001
DOI
10.1203/00006450-200109000-00014
ISSN
0031-3998