Wearable sweat sensors represent a rapidly advancing field in non-invasive health monitoring, leveraging sweat’s rich composition of biomarkers to provide continuous insights into an individual’s physiological state. Traditional diagnostic methods, such as blood tests and imaging techniques, are often invasive, costly, and require specialized equipment, highlighting the need for more accessible alternatives. Despite the promising potential of wearable sweat sensors, significant gaps remain in understanding the optimal integration of advanced materials and techniques to enhance sensor performance. Specifically, questions persist regarding the most effective methods for sweat extraction and multi-analyte detection in real-time applications. This review examines the current state of wearable sweat sensor technology, focusing on the innovative use of advanced electrochemical detection methods and nanomaterials. Materials such as carbon nanotubes, metal-organic frameworks, and noble metal nanoparticles have significantly improved the sensitivity and specificity of these sensors. The development and application of various sweat extraction techniques, including iontophoresis and microfluidic devices, are highlighted, facilitating efficient and uncontaminated sweat collection. Additionally, the capability of modern sensors to simultaneously monitor multiple biomarkers, offering a comprehensive view of an individual’s health, is explored. These advancements have profound implications for the field of medical diagnostics, as wearable sweat sensors can revolutionize early disease detection and personalized health management. The integration of these sensors with mobile health platforms promises to enhance continuous, non-invasive monitoring, making healthcare more accessible and cost-effective