Synthesis and in vivo efficacy evaluation of NSAIDs-verticinone esters

Objective: To synthesize non-steroidal anti-inflammatory drugs (NSAIDs)-verticinone esters and evaluate their efficacies in vivo. Methods: Four new compounds were synthesized by ester linkages between NSAIDs (dexibuprofen, indomethacin, dexketoprofen, naproxen) and verticinone based on twin drug theory. The antitussive, anti-inflammatory and anti-asthmatic activities of these new compounds were evaluated. Results: The 4 compounds were successfully synthesized and their structures were identified. Compounds 3, 4 and 5 had an antitussive activity, prolonged latency period of cough and obviously inhibited cough. Compounds 2, 3 and 5 showed a significant anti-inflammatory activity. All these compounds had a potential anti-asthmatic activity. Compounds 3 and 5 had a better pharmacological activity than others. Conclusion: The NSAIDs-verticinone esters show the original activities of NSAIDs and verticinone and also enhance their activities, providing a basis for further studies.