Journal article
Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer
Abstract
Triple negative breast cancer (TNBC) is an aggressive disease which currently has no effective therapeutic targets and prominent biomarkers. The Sperm Associated antigen 5 (SPAG5) is a mitotic spindle associated protein with oncogenic function in several human cancers. In TNBC, increased SPAG5 expression has been associated with tumor progression, chemoresistance, relapse, and poor clinical outcome. Here we show that high SPAG5 expression in …
Authors
Canu V; Vaccarella S; Sacconi A; Pulito C; Goeman F; Pallocca M; Rutigliano D; Lev S; Strano S; Blandino G
Journal
Cell Death & Disease, Vol. 15, No. 8,
Publisher
Springer Nature
DOI
10.1038/s41419-024-06987-x
ISSN
2041-4889