Journal article
MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product
Abstract
Forazoline A is a structurally complex PKS-NRPS hybrid produced by marine-derived Actinomadura sp. During the course of studies highlighting the application of IFS analysis as a powerful tool for natural products analysis, we were alerted to an earlier misinterpretation with respect to forazoline A structure elucidation. In particular, IFS reveals that forazoline A contains a thioketone moiety rarely seen in secondary metabolites and, thus, …
Authors
Zhang F; Wyche TP; Zhu Y; Braun DR; Yan J-X; Chanana S; Ge Y; Guzei IA; Chevrette MG; Currie CR
Journal
Organic Letters, Vol. 22, No. 4, pp. 1275–1279
Publisher
American Chemical Society (ACS)
Publication Date
February 21, 2020
DOI
10.1021/acs.orglett.9b04535
ISSN
1523-7060