Journal article
The Significance of Thyroid Hormone Receptors in Breast Cancer: A Hypothesis-Generating Narrative Review
Abstract
BACKGROUND: Breast cancer (BC) is frequently diagnosed among Canadian women. While targeted therapies are available for most BC patients; treatment resistance is common and novel therapeutic targets are of interest. Thyroid hormones (TH) bound to thyroid hormone receptors (THR) influence cell proliferation and differentiation; they are also involved in the growth and development of normal breast tissue. Evidence suggests that THRβ is a tumor …
Authors
Quan T; Cockburn J; Dhesy-Thind S; Bane A; Leong H; Geleff C; Devion C; Ajel N; Jerzak KJ
Journal
Current Oncology, Vol. 31, No. 5, pp. 2364–2375
Publisher
MDPI
DOI
10.3390/curroncol31050176
ISSN
1198-0052