Preprint
Spatial Multi-Omics Connect SHROOM3 and COL18A1 in Chronic Kidney Disease
Abstract
Abstract Shroom Family Member 3 ( SHROOM3) encodes an actin-binding protein that impacts kidney development. Genome-wide association studies (GWAS) identified CKD-associated common variants around SHROOM3 and Shroom3 knock-out mice develop glomerular abnormalities. We sought to evaluate the impact of genetically predicted SHROOM3 expression on kidney traits and the circulating proteome, and validate findings in a mouse model. Genetic …
Authors
Gaheer PS; Uppal N; Paul A; Mohammadi-Shemirani P; Perrot N; Paré G; Bridgewater D; Lanktree MB
DOI
10.1101/2024.02.09.24301246
Preprint server
medRxiv