Journal article
Canadian Multicentric Pan-TRK (CANTRK) Immunohistochemistry Harmonization Study
Abstract
Tumor-agnostic testing for NTRK1-3 gene rearrangements is required to identify patients who may benefit from TRK inhibitor therapies. The overarching objective of this study was to establish a high-quality pan-TRK immunohistochemistry (IHC) screening assay among 18 large regional pathology laboratories across Canada using pan-TRK monoclonal antibody clone EPR17341 in a ring study design. TRK-fusion positive and negative tumor samples were …
Authors
Hyrcza MD; Martins-Filho SN; Spatz A; Wang H-J; Purgina BM; Desmeules P; Park PC; Bigras G; Jung S; Cutz J-C
Journal
Modern Pathology, Vol. 37, No. 1,
Publisher
Elsevier
Publication Date
1 2024
DOI
10.1016/j.modpat.2023.100384
ISSN
0893-3952