Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non-enzymatic Glycoside Hydrolysis and Transfer

Publisher This chapter attempts to provide a summary of the use of transition state (TS) analysis in understanding glycoside chemistry, as well as an overview of recent developments in the field. TS analysis is only one tool in any comprehensive analysis of reactivity and catalysis. It addresses both the principles and practice of TS analysis and recent advances in the understanding of hydrolysis and glycosyl transfer reactions of N- and …