Journal article
Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis
Abstract
Normothermic ex-vivo kidney perfusion (NEVKP) results in significantly improved graft function in porcine auto-transplant models of donation after circulatory death injury compared with static cold storage (SCS); however, the molecular mechanisms underlying these beneficial effects remain unclear. We performed an unbiased proteomics analysis of 28 kidney biopsies obtained at three time points from pig kidneys subjected to 30 min of warm …
Authors
McEvoy CM; Clotet-Freixas S; Tokar T; Pastrello C; Reid S; Batruch I; RaoPeters AAE; Kaths JM; Urbanellis P; Farkona S
Journal
Molecular & Cellular Proteomics, Vol. 20, ,
Publisher
Elsevier
Publication Date
2021
DOI
10.1016/j.mcpro.2021.100101
ISSN
1535-9476