Journal article
Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides In Vitro *
Abstract
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are captured by the urinary peptidome. To elucidate the early kidney response to chronic hyperglycemia, we conducted a peptidomic investigation into urines from otherwise healthy youths with type 1 diabetes and their non-diabetic peers using unbiased and targeted mass …
Authors
Van JAD; Clotet-Freixas S; Zhou J; Batruch I; Sun C; Glogauer M; Rampoldi L; Elia Y; Mahmud FH; Sochett E
Journal
Molecular & Cellular Proteomics, Vol. 19, No. 3, pp. 501–517
Publisher
Elsevier
Publication Date
3 2020
DOI
10.1074/mcp.ra119.001858
ISSN
1535-9476