Journal article
Mitochondrial-mediated inflammation and platelet activation in giant cell arteritis
Abstract
Markers of extracellular mitochondria are present in giant cell arteritis (GCA) patients. However, their role in promoting inflammation and platelet activation is no known. To investigate this, isolated mitochondria were opsonized with plasma from GCA patients or healthy individuals and incubated with peripheral blood mononuclear cells (PBMCs) or platelets and assessed for inflammatory cytokine production and platelet activation. Plasma from …
Authors
Michailidou D; Grayson PC; Hermanson P; Chapa JAG; Cuthbertson D; Khalidi NA; Koening CL; Langford CA; McAlear CA; Moreland LW
Journal
Clinical Immunology, Vol. 255, ,
Publisher
Elsevier
Publication Date
October 2023
DOI
10.1016/j.clim.2023.109746
ISSN
1521-6616