Journal article
BSBM-09 IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES ß-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) AS A DRIVER OF NON-SMALL CELL LUNG CANCER BRAIN METASTASIS
Abstract
Abstract
Brain metastasis occurs in up to 40% of patients with non-small cell lung cancer (NSCLC). Considerable genomic heterogeneity exists between the primary lung tumour and respective brain metastasis; however, the identity of the genes capable of driving brain metastasis is incompletely understood. Here, we carried out an in vivo genome wide CRISPR activation (CRISPRa) screen to identify molecular drivers of brain metastasis from a NSCLC …
Authors
Chafe S; Zhai K; Aghaei N; Miletic P; Brown K; Mobilio D; Venugopal C; Kieliszek A; Hynds R; Lam F
Journal
Neuro-Oncology Advances, Vol. 5, No. Suppl 3, pp. iii2–iii2
Publisher
Oxford University Press (OUP)
Publication Date
August 4, 2023
DOI
10.1093/noajnl/vdad070.005
ISSN
0801-3284