Journal article
Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, Z-DEVD-aminoluciferin
Abstract
Apoptosis is a highly regulated process of programmed cell death essential for normal physiology. Dysregulation of apoptosis contributes to the development and progression of various diseases, including cancer, neurodegenerative disorders, and chronic heart failure. Quantitative noninvasive imaging of apoptosis in preclinical models would allow for dynamic longitudinal screening of compounds and facilitates a more rapid determination of …
Authors
Hickson J; Ackler S; Klaubert D; Bouska J; Ellis P; Foster K; Oleksijew A; Rodriguez L; Schlessinger S; Wang B
Journal
Cell Death & Differentiation, Vol. 17, No. 6, pp. 1003–1010
Publisher
Springer Nature
Publication Date
June 2010
DOI
10.1038/cdd.2009.205
ISSN
1350-9047