Journal article
Effects of Methimazole on the Onset of Type 2 Diabetes in Leptin Receptor-Deficient Rats
Abstract
We investigated the effects of methimazole, an anti-thyroid drug, on the onset of type 2 diabetes in Zucker diabetic fatty (ZDF) rats. For this, 0.03% methimazole was administered to 7-week-old, pre-diabetic ZDF rats in drinking water for 5 weeks and the animals were sacrificed at 12 weeks of age. Methimazole treatment to ZDF rats significantly reduced blood glucose levels, food intake, body weight, and serum T3 levels. Hepatocytes in ZDF-methi …
Authors
HWANG IK; KIM IY; KIM YN; YI SS; LEE YH; JU EJ; LEE IS; PARK I-S; WON M-H; YOON YS
Journal
Journal of Veterinary Medical Science, Vol. 71, No. 3,
Publisher
Japanese Society of Veterinary Science
Publication Date
2009
DOI
10.1292/jvms.71.275
ISSN
0916-7250