Gut-Brain rejuvenation: Identification of age associated changes in the neural firing pattern of myenteric primary afferent neurons and vagal fibres that are reversed by the aminosterol, squalamine

Vagus nerve signaling is a key component of the gut-brain axis and regulates diverse physiological processes that decline with age. Gut to brain vagus firing patterns are regulated by myenteric intrinsic primary afferent neuron (IPAN) to vagus neurotransmission. It remains unclear how IPANs or the afferent vagus age functionally. Here we identified a distinct ageing code in gut to brain neurotransmission defined by consistent differences in …