Transformation by and Oncogenicity of Human Adenoviruses

Just slightly more than 20 years ago, human adenovirus type 12 (Adl2) gained the distinction of being the first human virus shown to have oncogenic properties when Trentin et al. (1962) reported the induction of tumors following injection of the virus into newborn hamsters. Their observations were quickly confirmed and extended to other human adenovirus serotypes and to other rodents (Huebner et al., 1962, 1965; Rabson et al., 1964; Yabe et …