Journal article
Inhibitors of fatty acid synthesis counter resistance to last-resort antibiotic colistin
Abstract
Colistin-resistant bacteria require fatty acid synthesis to maintain cell envelope homeostasis; disrupting fatty acid biosynthesis leads to the remodelling of phospholipid composition and decreases the fluidity of the cell envelope. Inhibitors of fatty acid biosynthesis resensitize bacteria to colistin, allowing for the treatment of colistin-resistant bacterial infections in mice.
Journal
Nature Microbiology, Vol. 8, No. 6, pp. 1006–1007
Publisher
Springer Nature
Publication Date
June 2023
DOI
10.1038/s41564-023-01384-0
ISSN
2058-5276