Journal article
HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation
Abstract
BACKGROUND: The SREBP/SCAP/INSIG complex plays an essential role in SREBP activation and de novo lipogenesis. Whether the activation process is affected by hydroxysteroid 17-beta dehydrogenase 6 (HSD17B6) remains unknown.
METHODS: SREBP's transcriptional activities were analyzed using an SRE-luciferase (SRE-luc) reporter in 293T cells, Huh7 hepatoma cells, and primary human hepatocytes following a variety of conditions, including ectopic …
Authors
Wei F; Gu Y; He L; Kapoor A; Lin X; Dong Y; Su Y; Neira SV; Tang D
Journal
Metabolism, Vol. 145, ,
Publisher
Elsevier
Publication Date
August 2023
DOI
10.1016/j.metabol.2023.155631
ISSN
0026-0495