Journal article
Effect of a Run‐In Period on Estimated Treatment Effects in Cardiovascular Randomized Clinical Trials: A Meta‐Analytic Review
Abstract
Background A run-in period may increase adherence to intervention and reduce loss to follow-up. Whether use of a run-in period affects the magnitude of treatment effects is unknown. Methods and Results We conducted a meta-analysis comparing treatment effects from 11 systematic reviews of cardiovascular prevention trials using a run-in period with matched trials not using a run-in period. We matched run-in with non-run-in trials by population, …
Authors
Murphy RP; O’Donnell MJ; Nolan A; McGrath E; O’Conghaile A; Ferguson J; Alvarez‐Iglesias A; Costello M; Loughlin E; Reddin C
Journal
Journal of the American Heart Association, Vol. 11, No. 20,
Publisher
Wolters Kluwer
Publication Date
October 18, 2022
DOI
10.1161/jaha.121.023061
ISSN
2047-9980