Journal article
Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema
Abstract
In subjects with chronic obstructive pulmonary disease (COPD), hyperpolarized xenon-129 ((129)Xe) magnetic resonance imaging (MRI) reveals significantly greater ventilation defects than hyperpolarized helium-3 ((3)He) MRI. The physiological and/or morphological determinants of ventilation defects and the differences observed between hyperpolarized (3)He and (129)Xe MRI are not yet understood. Here we aimed to determine the structural basis for …
Authors
Kirby M; Svenningsen S; Kanhere N; Owrangi A; Wheatley A; Coxson HO; Santyr GE; Paterson NAM; McCormack DG; Parraga G
Journal
Journal of Applied Physiology, Vol. 114, No. 6, pp. 707–715
Publisher
American Physiological Society
Publication Date
March 15, 2013
DOI
10.1152/japplphysiol.01206.2012
ISSN
8750-7587
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAged, 80 and overAnalysis of VarianceContrast MediaDiffusion Magnetic Resonance ImagingFemaleHeliumHumansLungMaleMiddle AgedPlethysmographyPredictive Value of TestsPulmonary Disease, Chronic ObstructivePulmonary EmphysemaPulmonary VentilationSeverity of Illness IndexSignal-To-Noise RatioSpirometryTomography, X-Ray ComputedXenon Isotopes