Journal article
Investigation of N,N,N‑Trimethyl-L-alanyl-L-proline Betaine (TMAP) as a Biomarker of Kidney Function
Abstract
Glomerular filtration rate (GFR) is the most widely used tool for the measurement of kidney function, but endogenous biomarkers such as cystatin C and creatinine have limitations. A previous metabolomic study revealed N,N,N-trimethyl-L-alanyl-L-proline betaine (TMAP) to be reflective of kidney function. In this study, we developed a quantitative LCMS assay for the measurement of TMAP and evaluated TMAP as a biomarker of GFR. An assay to measure …
Authors
Sidor NA; Velenosi TJ; Lajoie GA; Filler G; House AA; Weir MA; Thomson BK; Garg AX; Renaud JB; McDowell T
Journal
ACS Omega, Vol. 8, No. 17, pp. 15160–15167
Publisher
American Chemical Society (ACS)
Publication Date
May 2, 2023
DOI
10.1021/acsomega.3c00153
ISSN
2470-1343