Journal article
The Effect of Mipomersen in the Management of Patients with Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis of Clinical Trials
Abstract
Background: Familial hypercholesterolemia (FH) lead to significant adverse effects in coronary arteries. Mipomersen is a second-generation antisense oligonucleotide that inhibits the synthesis of apolipoprotein B-100, an essential component of low density lipoprotein (LDL), and thus decreases the production of LDL. We aimed to determine the effect of mipomersen in patients with FH. Methods: We searched Ovid Medline, Ovid EMBASE, WHO ICTRP …
Authors
Astaneh B; Makhdami N; Astaneh V; Guyatt G
Journal
Journal of Cardiovascular Development and Disease, Vol. 8, No. 7,
Publisher
MDPI
DOI
10.3390/jcdd8070082
ISSN
2308-3425