Preprint
Systematic review of basket trials, umbrella trials, and platform trials: A landscape analysis of master protocols
Abstract
Background Master protocols, classified as basket trials, umbrella trials, and platform trials, are a novel approach that offers enhanced efficiency and a more ethical approach to trial evaluation. Despite the many advantages of these designs, they are infrequently used. Methods We conducted a landscape analysis of published master protocols using a systematic literature search to determine what trials have been conducted, with an overall goal …
Authors
Mills EJ; Park JJ; Siden E; Zoratti MJ; Dron L; Harari O; Singer J; Lester RT; Thorlund K
DOI
10.21203/rs.2.9437/v1
Preprint server
Research Square