Journal article
Impact of Allocation Concealment and Blinding in Trials Addressing Treatments for COVID-19: A Methods Study
Abstract
We aimed to assess the impact of allocation concealment and blinding on the results of coronavirus disease 2019 (COVID-19) trials, using the World Health Organization COVID-19 database (to February 2022). We identified 488 randomized trials comparing drug therapeutics with placebo or standard care in patients with COVID-19. We performed random-effects meta-regressions comparing the results of trials with and without allocation concealment and …
Authors
Zeraatkar D; Pitre T; Diaz-Martinez JP; Chu D; Rochwerg B; Lamontagne F; Kum E; Qasim A; Bartoszko JJ; Brignardello-Peterson R
Journal
American Journal of Epidemiology, Vol. 192, No. 10, pp. 1678–1687
Publisher
Oxford University Press (OUP)
Publication Date
October 10, 2023
DOI
10.1093/aje/kwad131
ISSN
0002-9262