Molecular Transducers of Human Skeletal Muscle Remodeling Under Different Loading States

Loading of skeletal muscle leads to remodeling of myofibrillar and extracellular matrix proteins to withstand metabolic stress and unloading results in the opposite. In humans, the heterogenous response to altered loading greatly complicates molecular modeling of the underpinning processes. We utilized a within-person paired Hypertrophy and Atrophy (‘HypAt’) strategy that reduced response heterogeneity by ~40%. We applied a new genome-wide …