Preprint
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
Abstract
ABSTRACT Objective: The metabolic master-switch AMP-activated protein kinase (AMPK) mediates insulin-independent glucose uptake in muscle and regulates the metabolic activity of brown and beige adipose tissue (BAT). The regulatory AMPKγ3 isoform is uniquely expressed in skeletal muscle and also potentially in BAT. Here, we investigated the role that AMPKγ3 plays in mediating skeletal muscle glucose uptake and whole-body glucose clearance in …
Authors
Rhein P; Desjardins EM; Rong P; Ahwazi D; Bonhoure N; Stolte J; Santos MD; Ovens AJ; Ehrlich AM; Garcia JLS
DOI
10.1101/2021.03.05.433354
Preprint server
bioRxiv