Preprint
Role of microRNA-dependent PTEN downregulation in the resistance to PI3K inhibitor alpelisib in head & neck squamous cell carcinoma
Abstract
Head and neck squamous cell carcinomas (HNSCCs) frequently harbor alterations in the PI3K signaling axis and, particularly, in the PIK3CA gene. The promising rationale of using PI3K inhibitors for the treatment of HNSCC has, however, clashed with a spontaneous development of resistance over time, observed both in PDX models and cell lines. Aimed at identifying valuable targets to circumvent acquired resistance to the PI3Kα inhibitor alpelisib …
Authors
Pulito C; Ganci F; Frascolla C; Sacconi A; Benedetti A; Manciocco V; Covello R; Morrone A; Pellini R; Muti P
DOI
10.21203/rs.3.rs-2582430/v1
Preprint server
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