Altered Resting-State Functional Connectivity in the Anterior Versus Posterior Hippocampus in Post-traumatic Stress Disorder: The Central Role of the Anterior Hippocampus

Abstract Background Post-traumatic stress disorder can be viewed as a memory disorder, with trauma-related flashbacks being a core symptom. Given the central role of the hippocampus in autobiographical memory, surprisingly, there is mixed evidence concerning altered hippocampal functional connectivity in PTSD. We shed light on this discrepancy by considering the distinct roles of the anterior versus posterior hippocampus and examine how this …