Submicron particle size distribution determination using light scattering and particle chromatography. Evaluation of the techniques and their application to on-line measurements

The capability of turbidimetry, dynamic light scattering, packed column chromatography, and capillary hydrodynamic chromatography to provide the full particle size distribution (PSD) or an average of the PSD of submicron particles has been investigated. Turbidimetry can provide the full PSD of suspensions of submicron spherical particles when the ratio of the refractive index of the particles to that of the medium is larger than 1.15. In any …