Preprint
Human coronaviruses disassemble processing bodies
Abstract
Abstract A dysregulated proinflammatory cytokine response is characteristic of severe coronavirus infections caused by SARS-CoV-2, yet our understanding of the underlying mechanism responsible for this imbalanced immune response remains incomplete. Processing bodies (PBs) are cytoplasmic membraneless ribonucleoprotein granules that control innate immune responses by mediating the constitutive decay or suppression of mRNA transcripts, including …
Authors
Kleer M; Mulloy RP; Robinson C-A; Evseev D; Bui-Marinos MP; Castle EL; Banerjee A; Mubareka S; Mossman K; Corcoran JA
DOI
10.1101/2020.11.08.372995
Preprint server
bioRxiv