Interaction of Platelets with Surfaces: A Factorial Study of Adhesion and Associated Release of Serotonin

Adhesion of platelets to several polymer surfaces and the release of serotonin from adherent platelets have been investigated. The platelets were washed, labelled with 51Cr and 14C-serotonin and suspended in media containing different concentrations of red cells, albumin and fibrinogen. The apparatus was a couette flow device operated under well-characterised flow and transport conditions. Adhesion and release were measured by counting …