Journal article
Effect of Multiple Gene Transfers of Insulinlike Growth Factor I Complementary DNA Gene Constructs in Rats After Thermal Injury
Abstract
HYPOTHESIS: Multiple subcutaneous injections of cholesterol-containing cationic liposomes encapsulating the complementary DNA (cDNA) gene for insulinlike growth factor I (IGF-I) increase the rate of transfected skin cells and result in increased IGF-I protein levels in the skin with subsequent improvement in wound healing when compared with a single injection.
SETTING: Laboratory.
Authors
Jeschke MG; Barrow RE; Hawkins HK; Chrysopoulo MT; Perez-Polo JR; Herndon DN
Journal
JAMA Surgery, Vol. 134, No. 10, pp. 1137–1141
Publisher
American Medical Association (AMA)
Publication Date
October 1, 1999
DOI
10.1001/archsurg.134.10.1137
ISSN
2168-6254