Journal article
IGF-I gene transfer in thermally injured rats
Abstract
Exogenous insulin-like growth factor-I (IGF-I) is known to improve the pathophysiology of a thermal injury, however, deleterious side-effects have limited its utility. Cholesterol-containing cationic liposomes that encapsulate complementary DNA (cDNA) are nonviral carriers used for in vivo gene transfection. We propose that liposome IGF-I gene transfer will accelerate wound healing in burned rats and attenuate deleterious side-effects …
Authors
Jeschke MG; Barrow RE; Hawkins HK; Yang K; Hayes RL; Lichtenbelt BJ; Perez-Polo JR; Herndon DN
Journal
Gene Therapy, Vol. 6, No. 6, pp. 1015–1020
Publisher
Springer Nature
Publication Date
June 1, 1999
DOI
10.1038/sj.gt.3300923
ISSN
0969-7128