Hepatic Gene Expression During Endotoxemia

PURPOSE: During the course of sepsis, endotoxins and cytokines activate Kupffer cells, induce the liberation and synthesis of adhesion molecules, and damage hepatocytes, which leads to septic liver failure. The interaction of the different hepatic cell types during these processes is not completely understood and may be clarified by microarray technology. MATERIALS AND METHODS: Seven Sprague Dawley rats received either an intraperitoneal …