Calcium/calmodulin‐dependent protein kinase II links hepatic cytosolic calcium release and apoptosis after burn injury

Liver integrity is essential to survival post burn as impaired liver function worsens prognosis in burn patients. Hepatocytes isolated after thermal injury have increased cytosolic calcium which is associated with depletion of endoplasmic reticulum (ER) calcium stores which is associated with upregulation of proteins involved in the ER unfolded protein response (UPR) pathway and activation of Jun N‐terminal kinase (JNK). Recently, it has been …