Journal article
Single-nuclei RNA Profiling Reveals Disruption of Adipokine and Inflammatory Signaling in Adipose Tissue of Burn Patients
Abstract
OBJECTIVE: We conducted a large-scale investigation of the systemic and adipose tissue-specific alterations in a clinical population of burn patients to identify factors that may influence hypermetabolism.
BACKGROUND: Previous research has identified chronic disturbances in adipose tissue inflammation, lipolysis, and browning, which may drive the perpetuation of hypermetabolism following the severe adrenergic stress of a burn injury. Given that …
Authors
Knuth CM; Ricciuti Z; Barayan D; Rehou S; Abdullahi A; de Brito Monteiro L; Jeschke MG
Journal
Annals of Surgery, Vol. 278, No. 6, pp. e1267–e1276
Publisher
Wolters Kluwer
Publication Date
December 2023
DOI
10.1097/sla.0000000000005880
ISSN
0003-4932