Journal article
Crohn’s disease proteolytic microbiota enhances inflammation through PAR2 pathway in gnotobiotic mice
Abstract
Emerging evidence implicates microbial proteolytic activity in ulcerative colitis (UC), but whether it also plays a role in Crohn's disease (CD) remains unclear. We investigated the effects of colonizing adult and neonatal germ-free C57BL/6 mice with CD microbiota, selected based on high (CD-HPA) or low fecal proteolytic activity (CD-LPA), or microbiota from healthy controls with LPA (HC-LPA) or HPA (HC-HPA). We then investigated colitogenic …
Authors
Santiago A; Hann A; Constante M; Rahmani S; Libertucci J; Jackson K; Rueda G; Rossi L; Ramachandran R; Ruf W
Journal
Gut Microbes, Vol. 15, No. 1,
Publisher
Taylor & Francis
Publication Date
December 31, 2023
DOI
10.1080/19490976.2023.2205425
ISSN
1949-0976