Journal article
Natural Killer Cell-Derived Interferon-γ Regulates Macrophage-Mediated Immunopathology During Viral Infection
Abstract
Regulation of immune responses during viral infection is critical to preventing the development immunopathology that impairs host survival. Natural killer (NK) cells are well known for their antiviral functions that promote viral clearance; however, their roles in limiting immune-mediated pathology are still unclear. Using a mouse model for genital herpes simplex virus type 2 infection, we find that NK cell-derived interferon-γ directly …
Authors
Feng E; Monteiro JK; Portillo AL; Balint E; Ashkar AA
Journal
Journal of Infectious Diseases, Vol. 228, No. 7, pp. 834–839
Publisher
Oxford University Press (OUP)
Publication Date
October 3, 2023
DOI
10.1093/infdis/jiad084
ISSN
0022-1899