Journal article
The gut microbiome restores intrinsic and extrinsic nerve function in germ‐free mice accompanied by changes in calbindin
Abstract
BACKGROUND: The microbiome is essential for normal myenteric intrinsic primary afferent neuron (IPAN) excitability. These neurons control gut motility and modulate gut-brain signaling by exciting extrinsic afferent fibers innervating the enteric nervous system via an IPAN to extrinsic fiber sensory synapse. We investigated effects of germ-free (GF) status and conventionalization on extrinsic sensory fiber discharge in the mesenteric nerve …
Authors
Neufeld KAM; Perez‐Burgos A; Mao YK; Bienenstock J; Kunze WA
Journal
Neurogastroenterology & Motility, Vol. 27, No. 5, pp. 627–636
Publisher
Wiley
Publication Date
May 2015
DOI
10.1111/nmo.12534
ISSN
1350-1925