Journal article
SC-33POLYCOMB GROUP PROTEIN Bmi1 CONTROLS NEURAL STEM AND PROGENITOR CELL MAINTENANCE AND GLIOBLASTOMA TUMOUR DEVELOPMENT
Abstract
Bmi1, a polycomb group protein is required for self-renewal of neural stem and progenitor cells (NSPCs). Elevated Bmi1 expression is observed in most brain tumours, including glioblastoma (GBM). GBM, one of the most aggressive and heterogeneous tumours is known to possess a subpopulation of brain tumour initiating cells (BTICs) that have acquired stem cell properties and are exclusively capable of driving tumour formation in a human-mouse …
Authors
Vora P; Venugopal C; Qazi M; Mahendram S; McFarlane N; Singh S
Journal
Neuro-oncology, Vol. 16, No. Suppl 5, pp. v204–v204
Publication Date
November 2014
ISSN
1522-8517